I bought my wife a 6mm 30 plus years ago and she still wacks deer with it. The .243 is much easier to find components for so it would probably be the better choice but for as little as my wife shoots it the 6mm has worked out great! She has taken deer out to 400 plus with it. I was loading the 80 grain Barnes TTSX but we started shooting factory ammo in it and the 95 grain SST from Hornady has worked great as well.