Every mono out there is most definitely different the same way for every other bullet construction. Alloy makes a huge difference the method of initiating expantion is different.
I want and need a bullet to shed weight, I don't always shoot an elk at a range where you'll see any effect other than mechanical injury to the internal organs. A Barnes that is shot to far will open just fine but you'll have a wound channels the size of the bullet and no more, takes a cow elk better than a half hour to succumb to a hit with a slow but open Barnes. A Hammer bullet with the right alloy and tip let's the bullet, down to the hole turn into large chunks of frag and an elks lungs will look like they snorted a grenade with excellent mechanical injury making a quick kill. Barnes will deflect on an elk shoulder sometimes because of not shedding all that frontal area, I saw about a 30 percent failure with Barnes 168's in a 300 WBY to penetrate into the chest, Hammers are the ONLY mono I've not seen a deflection or failure to penetrate an elk shoulder.
On the bullet core concentricity issues you replace that with issues from bullet to bullet consistent metelurgy that effects balance, a mono will ONLY be as good as the alloy supplied, this is why you aren't seeing monos crushing 1000 yard bench rest, I wish they could because the exterior dimensions can be contolled to the tenth and teeeked as needed.