Favourite or what makes most sense?
Most of the old calibers do just as well as any new/proprietary ones at a lower cost. The animal will not realize the 150 fps difference. My view is if you have a .308, .303, or 7mm Rem Mag you have the longer ranges covered for large game. the 30-30, 35 Rem etc. do well at 200 yards or so, there are of course others very similar. Bringing your proprietary hand loads way up north to hunt and lose them, or get them wet you may be without a gun.
For one caliber you can't beat a .308 for all purpose hunting and virtually any store will carry them.