Well, I don't hunt antelope in CO or WY, but I live in Montana and hunt antelope almost every year (didn't get drawn this year for the first time in 28 years), but I am pretty sure the antelope are just as easy to kill. So, there are lots of calibers that will work just fine. The 22s, even the 22-250 are a little light - mostly because of wind - but just about anything else will do. Here are the most important points (more important than caliber) to keep in mind:
1. Forget about what you read in the hunting magazine - long shots are not required - always try to get as close as possible. Stalking antelope is more fun than shooting them. I have killed from as close 40 yards and never farther than 350.
2. But be prepared (practice) to shoot a lot farther. Know your limit and stick to it no matter what. I always try to practice a lot farther than I would shoot because it is a confidence-builder. (If I am good at 450 yds., a 350 yds. shot is very doable.)
3. Know where you need to hold at different distances AND get/use a range finder. I have seen hunters empty a whole magazine at animals that were standing perfectly still and miss every single shot because they had no idea of the distance. And the critters never even reacted to the shots - that's how bad those misses were! As for antelope, in particular, if not used to hunting them, most folks think they are farther away than the really are because of their small size.
My best goat ... so far!
Good luck with your plans!
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