What 22cal would you build?

22 GT is a great option. No problem with dies or brass.
I was looking at that one as well. I think the 22 dasher wouldn't have the speed I'm looking for but the 22gt would. I was also looking at the 224TTH which is a 6rem necked down. The main downside is quality brass that's available. I'd like to stay under 45gr of powder.
 
I wished I had a 1:8 twist throated for heavy 22's. Right now my 22-250 is 3600 fps with 55 grains. It has more to give as an AI or another necked down case, but that 1:12 twist is holding it back. At 1:8 twist you need to do what Butterbean is doing, going to a solid mono and therefore throating it to accept a mono you prefer. As is, the 22-250 is a little hard on barrels. Do you mind that?
 
22 Creedmoor 1-7 twist
 

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I wished I had a 1:8 twist throated for heavy 22's. Right now my 22-250 is 3600 fps with 55 grains. It has more to give as an AI or another necked down case, but that 1:12 twist is holding it back. At 1:8 twist you need to do what Butterbean is doing, going to a solid mono and therefore throating it to accept a mono you prefer. As is, the 22-250 is a little hard on barrels. Do you mind that?
I don't shoot high volume so if I can get 1200-1500 rounds out of a hunting rifle I'm happy. But if I'm burning a barrel before I burn a brick of primers I'm probably not going to rebarrel with that cartridge.
 
I was thinking 22 Grendel or 22 dasher.
Then I'd say split the difference, and avoid fireforming and keep the longer case neck with 22 BR. But whatever interests you, 22 Dasher would be even more rare.

But you also asked for recommendations on the whole setup. I've got a 6 BRA Tikka so I can tell you the platform works no problem for BR cases, at least with the MDT 12-rounders, so that's what I'd recommend.
 
I have a simple garden variety .22-.250. McGowen 26", #4 McGowen contour, 7.7 twist, 5R.
I like the Hornady 75 ELDM's with RL 16 but also use - Hornady 75 HpBt & Staball, Hunter, 4000MR, T8000, IMR4831, H4350, AA4350, SW4350, H414.
I expect the barrel will last 1,500 rounds. My loads are moderate. I use whatever suitable powder I can get. I wish .22-.250 brass came with small rifle primers.

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Staball has been a disappointment. Two years ago, I developed a nice load using H414 at cool temperatures. but when I shot same at 95 deg. pressures spiked. The .224 75 ELD remains my bullet of choice & RL16 my powder of choice for my .22-.250's. .22-.250 loads using the 75 ELD are good for 600 yards plus and swat down small rodents. I might get another 150-fps using Lapua brass & RL16. Wifey shoots the Hornady 75 hpbt out of her 9 twist .223 at 2800 fps at steel.
 
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