I find these post entertaining because so many cannot pick their favorite "not plural" caliber/ cartridge.Well here we go
Thick cover.
bow 460sw 45colt or 32 special
Medium range 264 win/ 270 wsm
Long range 264 win or 300 win
Overall 264
My ultra cheap Ruger American in .270 loves the 130 and 140 American Whitetail and they both work great on eastern deer. Just got the last box of ELD-X precision hunter in 178gr. For .308 On the east coast I think at my local Dick's Sporting Goods. Planning on sitting on a pipeline this fall and wanted something that can reach out a bit. On a slightly different note, I know Dick's Sporting has received a bashing for their lack of 2nd amendment support, but it should be noted that their prices on the ammo they have in stock are pretty much pre-pandemic across the board. Don't see a lot of that these days. Just saying.I killed my first two deer with a .270, then went to 308 and 6.5 Creedmoor. This year I'm going back to the .270 and using my Dad's Winchester Model 70 classic with factory ELD-X Precision Hunters or American Whitetail. It likes both just fine. I can't wait til November.
My son has killed two deer with 123 gr SSTs from a 6.5 Grendel upper on my AR. I bought one of Andy Holbein's Grendel Hunter uppers for him. He's still not big enough for a compact bolt gun. The AR with the stock collapsed all the way fits him perfectly.