I agree that predictability is desired but in many cases no more than a pipe dream. One chooses a particular cartridge/bullet combination based on their experience in the area they normally hunt and the desired prey. There are however way too many variables involved in hunting to simply state that any one cartridge or bullet combination will have proven and consistent performance. You make a choice based on experience and then modify your actions to make that choice work in any given situation you come by while hunting. That is why they call it, " Hunting, " instead of planned execution.
Well no.
Bullets more often than not perform as designed so it's up to us to match the bullets we choose to our targets. That includes not just the size and thickness/toughness of the hair, hide, meat, and bone combination but the intended point of impact.
Bonded bullets are specifically designed not to break up or shed more than about 75% of their weight even when punching through hard bone.
Thin, light jacketed bullets are the opposite, they are designed to shed maximum weight even when hitting soft areas of the vitals avoiding all heavy bones.
The Accubond is probably not the most desirable bullet if you prefer a behind the shoulder shot on a light bodied deer, there's just not enough resistance to get it to mushroom consistently so you may not get the expansion you want.
Conversely if you're trying to punch the shoulders and spine with the SST, BT, or Amax, you stand a good chance of not getting enough penetration and having them simply shell out on contact.
That's why for best results we need to consider not only the size and weight of our intended target, but the intended range they are to be shot at.
Then you put it all together with shot placement respecting the game and the bullet you chose and put it where it's most likely to give you the best results consistently.
Then of course we can talk about the different types of Mono's and how they are designed which is typically quite different and with no core to worry about bullet separation/breakup is of far less concerned. The problem with mono's then is that for the most part they don't give you the same diameter hole due to limited expansion so again, you have to figure that into your equation.
When everyone was killing their game at 30-150yds shooting grampa's old .30-30 or 30-06 shooting Remington Corelock or Silvertips things were far less complicated for sure.
Today however we have an almost endless variety of bullets designed for different purposes, conditions, animals, and ranges so it takes more work on our part to get the job done quickly and cleanly every time.
Respect the game and the bullet and put it where it will do the most good and your odds of success are very high.