Two years ago out in Raton NM, we were Elk hunting and my rifle optics bit the dust. The only thing we had left was my friend's 6.5 Creedmoor. I love that caliber for sheep, whitetail, mulies, antelope etc., but I personally think it's a bit light for Elk. That said, I wound up using his rig with 140 gr Hornady ELD-X for a one shot 550 yd kill on a nice bull. I would have preferred to get within about 200 yds if I could have but alas, we low crawled as close as we could before they got spooky and he was disappearing over the ridge on the last hunt day. The weather conditions were really pretty favorable, so I took a slow, careful, well aimed shot and he dropped DRT. My buddy got his Elk with the same set up the day before, one shot at 260 yds. (cheater). I have a 6.5 PRC and would be much more comfortable using that especially with my handloaded 150 NABLR bullets coming out the gate at 2950 fps and .660 BC. That 6.5 PRC and 7 PRC are the deadliest midweight calibers I have ever seen...and I have ALL the classics as well to compare. I would not hesitate to use a 6.5 PRC on Elk out to about 500 yds. with good conditions and steady set up.