I pushed my S.I. back a little more than they did and I can run the 225's over 3000' easily.
The majority of my work with the 375 Ruger case has been in 17-18" specialty pistols, but I like to keep the 250s at around 2750 from an 18" barrel with a straight necked down 338/375 Ruger run at an OAL of 3.540". They'll go faster with some different powders but H4350 has been very easy to work with so I just stick with it. In a 28" barrel the 250 Berger is around 3050 with IMR 7828ssc.