If you are not using a chronograph then should stop and back off. Assume using a chronograph, then you should be paying attention to velocity adjusted for barrel length and ambient conditions (ie temp). If you hit expected velocity before max charge you should stop there. Used to not happen much, but not uncommon with all the custom, semi-custom, and factory guns with "match" chambers these days.
However, I am assuming you mean a case where velocity is significantly low (say 100 fps less than expected) and still getting some pressure signs. The first thing I would do is check with factory loads to see velocity and if has same pressure signs. I would also try different brand of brass. If get expected results with those I would keep paying attention to it but assume it is a bad lot of brass though I would keep loads on mild side until do not see signs again after more shooting
If do see pressure signs even on factory loads or other brass (again assuming significantly lower than expected velocity) then I would look for a mechanical cause of the pressure signs (web search is friend here). If cant figure it out then would just live with "slow gun" or send it on its way
Lou