I've hunt grizzly country a few times and either my 10mm Glock or my 357 GP-100 goes with me. I use ammunition with hardcast bullets for both. Does it compare to a 44 mag or 500 S&W, no, but both are capable rounds though. Just make sure if the situation ever arises, (hopefully it never does), that you are able to get to your sidearm quickly. I've come across a few people that wear their pistols at the small of their back in a IWB holster and wear their pack over it, making their sidearm inaccessible and therefore useless if needed.