I have been shooting RL-17 in my 375 Ruger since I purchased it in 2013, I load 1/2 to 1 full grain off of maximum and this loading with the 300gr Sierra BT bullets has proven extremely accurate out to 525 yards which is the furthest I have shot it. At 100 yards this combo shoots 3/4", it is still sub MOA at 525 yards. I am getting excellent brass life, 7-8 loadings, and then I use the brass for cast bullet plinking loads to get trigger time, I have 12 loading on some of my brass, and have yet to lose any. Powders I have tried are: RL-17, Varget, Ramshot Big Game, IMR 4007 SSC, and IMR 4350. I always come back to RL-17, I would say that the Ramshot Big Game is right there with accuracy, but I haven't been able to get my hands on any more of it. I may give H4350 a try, but I have about 7lbs of RL-17 to burn up first. My rifle is the Ruger Alaskan model before they went to the braked 20" barrel and it has the salt and pepper gray laminate stock, bullets I have tried are the old Hornady 300gr RN which it would shoot into 3/4" at 200 yards all day every day, Hornady DGX which shoot acceptable out to 250 or so, haven't shot them any further, the old Hornady FMJ or "Solid" as some called them, they shoot MOA and I have around 500 of them on hand, the Hornady 270gr RN shoot sub-MOA, but have a poor BC and so I only shoot them out to 300 yards, for long range work, I have only tried the Sierra 300gr BT bullets, and they shoot fantastic, it is a surprisingly tough bullet for a standard cup and core, and I wouldn't hesitate to hammer an elk or moose with one if I got the chance.
