I always took several rifles when culling in my younger days. During the late 70's, I had a Sako .243 with handloads, a Weatherby Mark V with handloads and a Winchester Model 70 with factory loads, all Remington primers.
All 3 rifles has missfires on that trip. I returned home and tossed everything Remington in the garbage and have never had another since.
I did however, have exoloding primers from those Winchester brass cased primers a few years back. I got lucky and bolt faces were not scored but I also ditched the newer Winchester primers. Used bucket loads of the old Winchester 120's and never had a problem.
These days I use Federal and CCI. No issues with either.