Most hunters, have never shot enough to really learn to shoot to the potential of even a one MOA capable gun system, and I put myself in this category for much of my 60+ year hunting career. I am a US Distinguished Rifleman and have had the privilege of leading the Florida State High Power rifle team for enough years to see what it took for a beginning shooter to master a rifle. It took an average around 6,000 rounds with quality feedback to achieve High Master. How many hunters do you think have mastered their rifle?
Learning to read the wind was one of the requirements and that was under more or less ideal conditions of a range which most, but not all, were relatively flat with a wind value that was constant across the full distance of the range.
For EIC or Leg matches, no sighters are allowed and when traveling to distant shooting ranges with different environmental conditions, even the best of the best would some times shoot a nine or eight at 600 yards on the first shot. For those of you unfamiliar with high power targets, an eight would be a miss by 9"-12". And I have seen national Champions do this.
Mountain hunting conditions are far more difficult than range conditions yet in spite of this I have personally managed to take many head of big game at long range. Some I know were just plain old good luck in that shooting errors were in my favor.
As an example I shot a Stone's sheep in British Columbia at long range with my 6.5 STW and misjudged the wind enough to hit the sheep just in front of the hip. But for some strange reason the bullet deflected on this sheep that was standing broadside and deflected enough that it exited through the off shoulder and resulted in a quick kill. It easily could have been an inhumane shot.
That Stone's sheep was more than 20 years ago and completed my grand slam. But now I know a lot more about long range shooting than I did then, and have much more capable equipment than I did then, but the distances and conditions I feel comfortable taking a shot on big game has reduced by several hundred yards. Just sharing my journey and learning on long range hunting, take it for what it's worth.