Well, if it were the only cartridge to shoot until my dying days, and you to take reloading out of the equation, the ole' 30-06 would probably be it. The recoil wouldn't be too much for a 70-80 year-old and the ammo is just about as available as anything out there, and in the widest variety of bullet weights and manufacturers. If I could choose one no matter what, I would probably go with the 300 RUM. Hurts to shoot, but you really can't argue with the performance. Long range, short range, bear, elk, moose, deer--it will kill anything the NA continent has to offer.