I know many guys in my area that deer hunt with 357 Mag lever guns and at the distances they claim to have killed deer, those lever guns aren't coming close to 1000ft lbs of energy or the velocity that some others have mentioned as their rule of thumb.
And how many countless deer were taken with black powder rifles with probably even less energy and velocity using non-expanding/low BC round balls of lead? Most of those old black powder rifles were horribly inaccurate. But I bet the people shooting never felt guilty about making an unethical shot.
In my younger days, I used a smooth bore 12 gauge to deer hunt for a few years. The slugs I used were only traveling 1300fps at the muzzle! With the terrible BC of those slugs, they must have been moving at Red Rider BB gun speeds by the time they connected with the animal. All 3 deer I shot with that gun died exactly where they were standing.
Ethical kills are a slippery conversation. I have an uncle in my hunting camp who wounds a deer every freaking year. Some years he has wounded 2 and not found them. All of his shots are under 100 yards and he is using a known good rifle. It ****es me off... But who am I to tell him that he shouldn't be hunting? He loves hunting! And has raised his boys to love hunting.
My opinion; if it's a small diameter bullet, it should be traveling pretty darn fast when it connects. If it has a lot of ft lbs of energy, it doesn't need to be traveling as fast. Really big diameter holes usually trump both.