I posed this question about the 7mm and elk. I had intended to build a 28 Nosler, but I don't need the punishment on my body with the recoil, so I decided that I would load the 168gr and the 180gr VLD-H bullets for any and all game elk size and up.
If the 243, 25'06, 260, 6.5 Creedmoor, PRC and 7mm-08 (there are others) will effectively kill elk within reason and when properly prepared, the 280 Ackley will do it in spades with either of the VLD-H bullets I mentioned.
I can use the money from the 28 Nosler build for more powder, primers, bullets, long range shooting classes/seminars and practice.
I don't necessarily tire of these threads, because there is always a couple of members with solid and differing advice that may have missed the other threads on the subject.