RL26 will likely give you more velocity than 22.I'll jump in since I got my 280ai with a 24" tube and I've been working up loads for it this summer. 160gr. AB with a pretty hot charge of 7828ssc nets just under 3080 with tight(to me) sd and es. Retumbo is a little slower in my gun.
I've never tried reloader brand powders but after reading a lot on here if like to give rl22 a go in this gun.
Don't do RL22, try RL23. Much more temp stable.
I agree on 23 for temp. Won't get quite the velocity of 26 but better where temp is an issue.ah you posted this as I was replying to elkaholic but temp sensitivity is my main concern with RL powders.