Consider this. My 6.5x06 24" Bbl, 1/8 twist. It drives the Nosler 140 AB ( BC .509 ) at 3075fps with no strain, using Rel 26. You can do the math on drop at various ranges. I have found 400yds to be a putt shot with this load. Exact same ballistics as the 6.5 PRC. So, 90 & 100gr bullets for varmints, tougher more robust bullets ( 120,130, 140 etc ) for heavier game. This rifle has taken numerous deer ( mature muley's ) & elk with 120 to 125 gr mono's. . The many different brands ( Barnes, Badlands Precision, Hammer, etc ) of copper mono's has made more modest caliber's considerably more capable to take heavy game without the harsh recoil of larger cals. Also have taken many elk over the years with my old wild cat , 6.5x308 (1994 era, Barnes 120gr X ) & my later purchased 260 Rem with the 120gr TSX/TTSx. The copper mono's have made these more relaxed recoil cartridges very capable to take heavy game. Lighter recoil, I feel puts more enjoyment into squeezing the trigger. Oh , don't forget , 100g bullets like the Nosler Partition & Barnes 100gr TTSX will easily take the largest deer, again with light recoil. What's not to like. Reduced recoil, flat trajectory. To me equals, enjoyable shooting.