As an archery hunter, primarily hunting from tree stands, you learn pretty quickly that placement depends on shot angle. In my view, the same generally applies to rifles, but we have a little wider margin for error if we know how our bullets perform (shock, fragmentation, ability to break bones and still penetrate) Depending on the angle of the animal, I'm picking placement so the bullet travels through the center of the chest, with the goal of destroying both lungs. If I can break shoulders in the process, that's what I'll choose. On a broadside, standing shot for an animal that's calm, I'll take the high shoulder shot every time I can if I have a good rest. If the animal has any angle to it (not broadside) that changes everything. If they're on high alert and could bolt away at any second, then I'd slide back into the V in case they move or hunch down before the bullet gets there. If you've got the right caliber and projectile, frontal shots, properly placed, are devastating. I'll risk sacrificing a shoulder, for the certainty of "dead right there" performance.