As others have stated, it can be very subjective based on several factors with the rifle, chamber, barrel being some of the greatest.
However for me, the 22 Hornet was always very touchy in loading and getting "good" groups. Acceptable for some ranges, but mine was hard to find those really good groups. Cases and loading process had to be very detailed.
On the other side, the 222Rem's I owned were all easy to make shoot well. Same for the 308's, and I'll throw in the 22-250AI's I have owned. They were all tack drivers with several loads. And how could I not mention the 6BR.