Zero. That is one of, if not the best, primer you can use. The 215 may cause issues with a ball powder and lower case volume but the 210 is one of the most popular primers for sure. Your situation is unique to me with the ram shot. I did a quick google and didn't see any results for magnum in the heavier bullet weights. Particularly with Hornady publication for the 147/153 it is not listed. I feel like this is one of those goofy combo's that creates a spike under certain conditions. 1-2 shots, no issue. These PRC's get barrels and chambers hot very very quickly. If you able to shoot non-strings and see no issues then I lean heavily toward the spike. If you can get your hands on H1000, RL26, N560-565, or maybe retumbo it'd be worth a test.