To bring this back toward topic, I think lighter for caliber premium bullets at higher speeds work better, and I have no science trying to back this up, just experience on my side from this year's deer.
I went with a 180gr Accubond in a 338 Federal. I have plenty of 338 bullets choose from, 160ttsx up to 225 Accubonds, and everything in between. I didn't have time to work up a 160 load, so I went with the highly accurate 180 Accubond load at 2735fps. It's a bit over 125fps over a 308 with a 180gr bullet, with a larger frontal impact.
I shot a good sized 10 point white tail, quartering towards me slightly, behind the shoulder. It literally blew a large chunk of lung out of the entrance hole, bullet was recovered opposite side in front of rear leg, 146 gr retained. Worked amazing.
I will try to upload pictures.
SHM