I use my MS at the beginning and at the end of my load development. I strap it on during my 'pressure testing'. I load one bullet going up in half grain increments for std., non-magnum calibers or full grain increments for large magnum calibers. I note the speed of each bullet for the charge used. I stop shooting when I find the pressure/velocity curve beginning to flatten out (normally happens right before your pressure spike). Signs of excessive pressure (cratered/flattened primer, sticky bolt, etc.) can be harder to spot in a custom rifle. But if you are monitoring the speed of each load, you will see where the increased charge no longer gives you the incremental jump in velocity you were seeing before. That helps establish the upper end for my ladder test.
Once I have my maximum safe load established, the MS comes off. I shoot my ladder, establish my nodes, then shoot groups with slightly varying powder charges from the lower to higher end of the node. Paper doesn't lie.
After my load has been selected, I then fine tune it using different seating depths and possibly different primers. I then strap the MS back on to the barrel to find out what my average velocity is for use in my ballistic calculations. It also helps confirm a low ES and SD. The velocity is what it is, and I don't want to possibly skew my results subconsciously by tracking my velocity as I develop a load.
To each his own. The MS has been great for me.