I read this whole thread and wonder do we actually expect a bullet to smash through a shoulder or even both shoulders at whatever distances or go through lungs with same bullet terminal performance with same accuracy? Bullet design is either soft tissue or tough enough to smash through. That is what I like about the bullets we can choose, "pick your poison" comes to mind when selecting a bullet.
Kind of reminds me of bowhunters "debating" mechanical versus fixed broadheads versus light and heavy mass/spine arrows, woodland versus plains, ground versus tree, etc.
Your weapon and your style, how you hunt and your accuracy potential will likely dictate what bullet or even what arrow setup you will use for the game you are hunting.
Which is why I still use the 200 AB in my 300WM after first bull I shot through front shoulder at 190 yds, lodged under hide on back shoulder beautifully expanded at about 80% weight retention after going through both shoulders of a decent size bull. Only crap I got was both shoulders had to be pared out due to damage. Accurate enough to the distances I shoot (600) and does the job. I tried the 200 ELD-X and shot well enough but didn't shoot any better so why change from a PROVEN performer.
Then again I didn't see anyone state the obvious 6.5CM will take out a Grizz at distances up to a mile