I didn't read this whole thread but I think most people are looking at this wrong, including OP.
You don't need any smoking hot cartridge, likely do it with something you already have, look into MPBR, (maximum point blank range).
You have to run the ballistics on the ammo you are using and then figure out the kill zone size on the animal you choose to target, then you set up your zero so the bullet will never rise out of this area and then figure out how far out before the bullet drops out, or there is calculators online.
For example, 257 Weatherby Mag, Shooting 110gr ELD-X @ 3250 fps. using a 10" kill zone
Sight in 3.3" high at 100 yards, this gives you a true zero at 336 yards and effective range to 395 yards.