Although I've always rifle hunted, I was bitten by the archery bug years ago, and almost all of my deer have been taken with a bow.
But things change and now I'm a certified rifle nut. However, the two places I get to do any serious hunting, Iowa and Virginia, have their seasons scheduled where muzzleloader season is during the premium time of yr. Iowa has no rifle season, so it's muzz only.....and In Va the first two weeks of Nov is muzz.
So my favorite deer rifle is my smoke pole.....which is bad news for the deer.
It's a smokeless McWhorter .45XML, Brux barrel, Borden action, McMillan stock....topped with a Leica 2.4-16x56.
She pushes a 325gr Pittman bullet 2900fps with 73.5g of imr-4198 behind it.
Farthest shot has been 389yds, but the gun will hold .5moa or less out to 700......although I'm not sure I can.
The only negative is the recoil is stiff. Nothing more than a large magnum, but some of us get recoil shy as we get older.