Never tried the 215s, I don't have a gun that is designed to shoot them. I do use the 180 gr .284 VLD hunting bullets though. I have shot a lot of both deer and elk with them, from 10 yards to 820 yards. I am leery of a shoulder shot at close range (under 150) particularly on an elk, and in my opinion they perform best past 400 yards in my rifle (3100 fps MV). I don't particularly like their total lack of knockdown on elk. Only ones I've had get knocked down on impact were two quartering on shots on the point of the shoulder that flat ironed them (one at 475 and the other at a guesstimated 175 running). Everything else at longer ranges on elk didn't seem to notice they were hit. I don't like that, but they do seem to kill good and they shoot so dang accurate out of my rifle that I keep using them. A couple years ago I shot a HUGE bodied 5x6 bull at 620 yards. quartering slightly away, hit him in the ribs and went through the off shoulder, he turned around, faced the other direction and I made an identical shot through the ribs and through the off shoulderblade. I only had the two bullets (had another rifle with me, but it was my only day off and I got home after midnight and managed to misplace all my bullets except the two that were in the magazine in the safe) so instead of keeping shooting I was laying there staring through the scope and he started to wobble and fell over. Both bullets were recovered perfectly mushroomed under the hide after penetrating the far shoulder blade. That won't happen at closer ranges/higher velocities with that bullet. But then it is dang hard to make a bullet that will perform the same at 50 yards and 700 yards out of the same rifle. A guy does the best he can and picks a bullet that will perform best at his expected range and compensates or doesn't shoot if the range is vastly different.
Example, I wouldn't take a 700 yard shot with a Remington Cor-lokt, not because I don't think it is a good bullet, but because it isn't designed for that kind of long range shooting and I wouldn't trust it hitting where I aimed, I also wouldn't take a shoulder shot with a Berger on an elk at 20 yards.