I've only been casting for about 10/12 years now, but I REALLY enjoy doing so. I cast for both rifle and handguns for projectiles .355 caliber and over. The .358", .375", .401", .430", and .458" handguns/rifles are my favorite. Next in line would be my .452" and .510" muzzleloaders.
But, regarding the 10mm Auto. First and foremost I am a hunter. I LOVE to handgun hunt and find it very rewarding to harvest game with a bullet I casted/loaded to take such animals - mostly deer and hogs (southeastern fella here). My current pet load for the 10mm Auto is a 200gr. Accurate Mold .40-200C of (30:1 alloy) 25% COWW - 75% SOFT to 1lb. pewter, about 11 BHN. In the last year I have begun powder coating and watched my groups tighten up by 50%!!! I was strongly against powder coating for the longest time until I tried (forced to) it for myself. . .VERY glad I did!!!
I shoot a Glock G40 MOS with a 6.5" KKM barrel and a few other specialties in this handgun. I have a Leupold DeltaPoint Pro sight and it is zeroed at 75yds. with the 40-200C bullet. My load is 11.5gr. Accurate #9, (YMMV start below) Starline brass, Winchester LPP, 200 gr. cast at a COAL of 1.260" with a muzzle velocity of 1320FPS (over a Lab Radar). I am VERY confident at taking Med. Game to the 75yrd. mark and can walk aluminum cans off the bench to 125yds. with this load/handgun. I do harvest deer (multiple) ever year with this combo and hogs as pest control seems like weekly with no issue. It is really a fun, accurate and lethal cartridge within 100 yards.
I know this will probably start a SERIOUS B.S. session. . .but all this talk of self-defense and hand loaded ammo, cast ammo, blah blah blah. . .is internet pot-stirring bullsh!t!!! Yes, if your running hunting cast loads (as I do) there is a chance of over-penetration, but it doesn't mean you're out of compliance with the law. You as the shooter have to take everything going on at the moment if you were to squeeze the SAID trigger. That said, I know MY AMMO, and what the capabilities are of what is loaded in my handguns. . .carry guns have "said load" hunting handguns have "said load". . .either way I feel "me & mine" are protected.
Just my $.02 on this matter. Take care and Happy New Year. Be safe out there.