I had an easy shot at 150 yards at a nice buck a few years back. I was using a new bullet I hadn't tried before. The buck ran with no blood trail. I still can't bring myself to try that bullet again, even though a clean miss is more likely than bullet failure, based on my experience with other bullets from that maker.
I don't mean to beat you up here, but in my experience, if you get lots of hair and no blood, that usually means a grazing shot, either top or bottom of the animal. When a sharp pointed bullet (even a fat one) goes in, it usually doesn't tear out any hair. If you had an exit wound, that will almost always leave a trail, and hair (one reason folks like Barnes).
I shot a cow elk with a Precision Rifle 340 gr. Dead Center this year, and it ran off with no blood trail. I found her 75 yards away with the top of her heart blown away. No exit wound, a little blood on her hide where the bullet entered, no hair, and no blood trail, not even a drop.
My butcher started me on Barnes bullets. She would put all of the bullets she found in the meat in a tray on her counter. Every Barnes bullet looked just like the advertisements, no metal loss, and perfect petals. I've used Barnes for years, and had DRT performance on elk and gemsbok, but I've had deer and bear run away after a shot. My conclusion is that it wasn't bullet failure, but shooter failure. I hunted for 13 years before I ever shot at a big game animal I didn't harvest. The first time it happened, I couldn't believe it. I saw the animal go down spectacularly, with its feet straight up in the air as it flew through the air. No blood. Being stubborn, I kept looking until I found the 4" tip of his antler. No accounting for how I missed an easy shot, but I keep that antler as a reminder of human error.
I have also used Bergers, and got performance just as advertised. I don't believe I'd shoot one directly at a shoulder bone. I've had pure lead muzzleloader bullets break in two on a shoulder bone at 90 yards (although it cracked the ball joint). Fortunately, the two split pieces went through the neck and lungs, so I recovered the elk within about 75 yards.