I ran charge weights up in QL for both powders to just before max pressure (see attached). Since QL is only a mathematical prediction tool, I use it to find a jumping off point from which I back down 7-10% for a starting load.
It would appear that Varget will be your best bet as max pressure and velocity can be reached without a compressed load. On the other hand, H4350 requires a 9% compressed load. FYI, QL data used presets of 2.8" COAL and 55 grains of H2O capacity.
I did find Varget data for the 150 BT on Nosler's web site (attached).