Until Hornady got involved, the 6.5's were all handloader's cartridges. It seems most have forgotten that the 6.5 Creedmoor was originally designed to work in an AR-10 type rifle. It was correctly dimensioned to fit in an AR-10 mag and to work well with the most streamlined 6.5mm bullets available at the time, without giving up powder capacity to do that.
For non-handloading bolt action shooters, the resulting benefit of the Creedmoor design was a turnkey package (once the rifle manufacturers woke up and started chambering factory rifles for the Creedmoor) of factory rifle and factory ammunition that offered both hunting and match ammo, made long range shooting accessible to more casual shooters, and did so with performance ammo correctly specd for a short action rifle and specd for the correct twist to work with the best 6.5mm bullets.
The 6.5 PRC offers more of the same, though it is dimensionally not a true short action cartridge. For a new shooter, it is hard to argue against either the Creedmoor or the PRC. They represent the easy button when it comes to accuracy and long range performance in factory rifles, using factory ammunition.
The .264 WM is a cartridge that will reward an advanced handloader with a factory rifle. I say advanced handloader because published data for the .264 WM is garbage. For the .264 WM to be worthwhile, it has to be treated like a wildcat cartridge, requiring the shooter who loads for it to be advanced enough to map his own load data. In a factory rifle, the .264 WM is still limited by its standard 9 twist barrel. It will still work with 140 VLD type bullets, but is not compatible with the latest and greatest 6.5mm bullets available.
It took a long time for powder technology to catch up with the case capacity available in the .264 WM. Even using the slowest of powders (such as Retumbo, RL-33, and VV N570), the .264 WM will still pressure out before running out of case capacity. With 140 VLD's, the .264 WM easily produces accuracy @ 3150 from a 26" barrel, at mild pressure levels.
Brass options have gotten much better than they once were. Forget .264 WM brass. ADG or Peterson 7mm Rem Mag brass is the way to go. Neck it down and go. Nothing more is required. For an advanced handloader, the .264 WM is the most direct path to this level of performance in a 6.5mm bore in a factory rifle.
In a full custom rifle, pick the bullet you want to shoot, how fast you want to shoot it, pick the right case capacity to get you where you want to be, and choose an appropriate barrel length. Anything on the 6.5 menu will make you happy if the specs are chosen properly.
On to personal preferences...
My personal taste in rifles leads me to not care about cartridge fit in short actions. With that in mind, my pick among the smaller cased 6.5's is the original 6.5x55. In a modern mauser length action, it has no OAL issues with any of the best available bullets. Loaded accordingly, it gives up less than 100 fps to the 6.5-284 Norma in the same barrel length. It's easy to tune. Top notch components are easy to source.
Among the fast 6.5's, my choice is the .264 WM. Current Winchester Model 70's chambered for it are a joy to shoot and carry. It is easy to source quality components and is easy to tune. With 140 class VLD type bullets, it is an excellent coyote, deer, and antelope cartridge in windy, open country.
I do not consider ANY 6.5 to be a legitimate elk cartridge, but I would not hesitate to load 140 Nosler Partitions and go elk hunting. An 8 twist aftermarket barrel and 150+ class bullets might do more to move the .264 toward being a legit elk cartridge, but there are other rifles in my safe that would be my first choice for that application.