I have had both 6.5-06 AI and still have a .280 AI. I personally love both cartridges and am planning on building another 6.5-06 AI. With that being said I think for a 140 grain bullet the .280 AI is the better choice. better selection of bullets in .284 in 140 grain options. Also you can buy headstamped .280 AI brass. dies are cheaper, more available, and the 6.5 is more suited towards a 130 grain bullet. The bullet selection is not great in 140 grain for 6.5mm bullets and you will have to spend time fire forming your brass. I own a .264 wm and feel that it is a much more suitable cartridge to shoot 140 grain bullets in .264 diameter. Im not a fan of the vanilla .270 which is a great cartridge, only for the fact everyone has one. That is why I am planning another 6.5-06 AI set up to shoot 130 grainers. it will be a dedicated Antelope rig. point in all my rambling is I would choose the .280 AI or .264 for 140 grain bullets, leaning more so to the .280 AI. just my thoughts