Velocity is what we really need to be looking at closely. If the bullet expands it will work. I've got a buddy who shot a bull elk (6point) at 930 yards with the 143 eldx. Bullet was recovered in far side hide and had a nice mushroom. Bull died within 20 seconds. Obviously this isn't ideal but if you put a bullet through the lungs it will work.
Sorry but that is not always the case. Even with best of bullet design and intentions, Murphy does not discriminate ...
.200g Hornady ELD-X precision hunter ammo
https://www.hornady.com/ammunition/rifle/300-win-mag-200-gr-eld-x-precision-hunter#!/ "NOT" looking for any debate, just sharing a "real world" experience. I already know many have success with it. Yesterday, my buddy harvested a nice 6X6 bull elk at 426 yards with his .300 WM. The bull was...
www.longrangehunting.com