For the criteria you describe there are several good options as has been mentioned. Having owned several and achieving exceptional performance and consistency for hunting and LR target shooting, I personally like the 6.5x284 running 2975-3000FPS with 140's. I haven't owned a 6.5 PRC but based on observing performance from others, it seems would be a comparable alternative. Barrel life depends on several factors. For my <.5MOA performance standard for 5 shots, I expect 1100-1500 rounds for the 6.5x384, not much different for most all of the usual suspects in this class of cartridge running comparable charge weights. Where in this range is dependent on rate of fire/heating, barrel, cleaning, etc. As a point of reference. PRS, using the same performance standard, my 260, 6.5x47 and 6.5CM with 40-42grs of powder rarely go much above 2200 rounds. Any pressure, neck length, etc difference between the cartridges does not seem to have any noticable influence on barrel life difference.