I use RL 16 anywhere I used H4350 but get ~100fps increased velocity. I reduce my H4350 load about 10% then work up from there. H4350 is a great powder. The only reason to switch to RL16 is if you cant find 4350. You probably wont go back to H4350 because RL16 is just as temp stable and accuracy is about as good and you get the extra 100fps....? RL 16 seems more available right now so if you are having trouble finding other powders, I think you might be surprised by this powder. I was so much that I have tried it in everything from my 6Creed to my 340 Wby.