.308 Starting load

[Rflshootr]

What about case capacity. I'm loading virgin Lapua brass and with 44 grains of Varget I'm getting a bit of crunch when I seat the bullet. Is that a concern and can I still go up to 45+ grains if I've got no pressure signs?

My Sierra program says 43.5 grains of Varget is max, in Federal brass with a Federal 210M primer, with their 168 HPBT. I'd back it down at least to 42.0 grains, and maybe more, for the first firing.
I wouldn't load the virgin brass with a max load. Wait until you have at least 1 firing on the brass, then work up in .5 grain increments.
Any time you change components, that can make everything different.