I would prefer the 1-8" twist. I've preferred the heavies for a long time primarily for advantages in close. More reliable penetration, busted bones, and longer wound channels. I'm not really a "long range" hunter of big game. Varmints and steel a long ways out the heavies also have advantages. It's the middle "normal" ranges where balancing causes some a bit of hesitation. The fact remains most of the heavies we're talking about will work fine here as well. A 30-06 with 200 grain bullets still retain enough FPS to expand
"If" I was younger and desired/needed one rifle that could do it all, the .300's would likely get the call. It would be set up intending to exploit the heavy bullets. I can't imagine a situation on this continent the .300 Norma, and others, loaded with the newer bullets like the 227 grain Hammer would not work for.
If one was required to put one in either, or both ends of a Brown Bear it would work. Elk in the alpine good to go. Occasional Rock Chuck sniping also capable.
Not all bullets are created equal, and I enjoy variety in my shooting. More difficult again is creating them identical, lot to lot, box to box, getting the individuals all the same is the challenge in my mind.