I'm running two 270 wby. One is a 26" and I was running 140 classic hunters at 3375 fps with RL 26 but this year I switched it to 110 ttsx at 3750 fps with RL23.
The second is a 27" 8 twist I'm running 150 accubond at 3275 fps with RL 26.
I wouldn't hesitate shooting the 150 accubond. Had great success with them last year.