My experience with .25 bullets for what it is worth....11 animals up to large cow elk shot with 100 gr. nosler ballistic tips 500-600 yds all broadside behind the shoulder double lungs. That large cow went 80 yds, the rest including mature whitetails and mule deer, traveled less than 50 yards before expiring. These animals were shot with a 25/300 Rum. with a muzzel velocity of 4250 fps, and a terminal velocity of between 2700-3000 fps. No exit wounds in any, bullets were all found under the hide on the far side. In the spring of 2009 that barrel had done all it could. I replaced it with a new barrel chambered in 25/300 win mag and it shoots the 100 gr. NBT's best at 3850. In the fall of 2009 on the eastern Colorado plains I shot a mature whitetail buck @673 broadside, double lung. He was out in the open and didn't know I was there....a friend with a spotting scope said he was hit good, so I didn't follow up with another shot. So we just watched, he trotted a ways and then laid down, and was looking around. It took 45 minutes for him to lay his head down and expire. Bullet went right through with bullet sized holes in both sides of the hide and the same in both lungs. Terminal velocity in this case was around 2100 fps. I realize this is a sample of one at that range, with that particular bullet, but I'm going to limit myself to 500 yds with this set up from now on.