I have killed deer with Rem 22/250's with 14 twists
55g Hornady Soft point with the cannalure
63g Sierra semi point is very accurate in a 14 twist
New bullet out that is fantastic, the Speer 55g Bonded Core bullet, and it is very, very accurate!
55g use Varget
63g use IMR, H, or AA4350
A 64g Winchester may stabalize out of the 14T, I have read it but not played around with it myself.
65g Sierra BTSP will not stabalize in a 14T, nor will a 60g V max.
I have shot half a dozen deer with the rem 700 with the 60g partition, and groups are 2" to 1.5". If you hit a deer on the shoulder with this bullet, you will throw away the front half of the deer, MV of 3450 fps.
I found that the 64-grain Winchester Power Point stabilizes just fine in a 14-inch twist 22-250. So does the 70-grain Speer semi-spitzer, and both kill deer well. I road-tested that pretty thoroughly on whitetails years ago. I shot more animals with the Winchester, because it shot more accurately in my particular rifle. Both bullets killed well, and neither made big holes. No blood-shot meat to speak of - just a dead deer with a hole through its lungs and a nickel-sized exit wound. Oddly, without extensive damage, all deer went down on the spot.
I also tried a custom bullet that was available at the time, from a company in Canada called Blue Point. They were a bonded core design, and I tried them in 60, 65, and 70 grains. Only the 60-grain bullet would stabilize, and groups were nothing special. I killed a couple of deer with it, and results were just like with the other bullets. I had more of the Winchester & Speer bullets, so that is what I used for the next several years.
I had a buddy in southern Oregon who used to use the 22-250 on blacktail deer, especially when his wife started hunting with him. He just used the garden-variety Sierra softpoints, in 55-grains. He told me that he saw no need to use anything heavier, or with a stiffer jacket - these worked just fine. The deer there aren't very large, and neither were the does I was shooting in Pennsylvania. I was careful to only take rib-cage shots, and never tried to shoot one right on the shoulder. He said that he never cut it that fine, and they shot their deer "in the chest" and didn't worry about whether or not they hit bones. He said it worked just like when they shot them with the 25-06 he favored for larger animals.
An added bonus I remember was that I could watch the deer fall down through the scope, due to lack of recoil. That was a little different for me at the time. If I had it to do again, I would probably try the 60-grain Nosler partitions, like somebody else recommended in this thread. I also saw that somebody liked the 55-grain Barnes, and there's a factory load available with those. Most of the other monolithic bullet designs are available in this diameter, and would probably work well. I doubt that anything much heavier than 55 grains would stabilize in the 14-inch twist, though. Factory loads would be the least expensive way to find that out, and you wouldn't be left with the rest of a 100-bullet box of bullets that don't work in your rifle.