So ive always said stuff like "300 or less is like wearing a dress"
And everything I have other than 22's and 556 is 300 and up... but.
Several years ago I worked on a ranch here in Montana, the 2 brothers that own it both had 22-250's and I was constantly razzing them about it.
One day we were feeding and a group of antelope were 250 yards from the 2 track.
I had a tag so the one brother handed me his 22-250 and ONE round.
I shot a doe in the neck, she never twitched, just dropped.
A few weeks later we were feeding again and there was this big muley with abnormal antlers, they were like baseball bats just going straight up, and they wanted him culled.
They had a 25-06 in the pickup so I grabbed it. The buck was a little over 100yds away and the first round was a dud (might have been a light strike) and the buck heard the action work and took off. His path was taking him around this little hill, but he jumped off a smaller knob that put him in my line of sight and I shot him.
He landed sprawled out and dead. We looked at the blood in the snow, you could see where he was when I hit him - mid jump and where he landed and slid... for a tiny bullet it did enormous damage.
I still prefer larger calibers, but I don't make as much fun of 22-250's and 25-06 any more... it's all about shot placement