I typically use a higher powder charge and get higher velocities with a cast bullet compared to a jacketed bullet of the same weight. In the 44 Mag I shot a 330gr hard cast bullet at the same velocity as a 300g jacketed bullet, and used almost 2.0gr more H110. I had the same results with all the other magnum revolvers as well. Using the right alloy or a gas check will prevent damage to the base of the bullet and help with some of the fouling and accuracy problems too.
I never had any issues shooting cast bullets in a factory Glock barrel as long as I used the proper bullet alloy. Shoot soft lead in just about any gun with velocities over 1000 fps and you're going to have a mess to clean out of the barrel, unless you use gas checked bullets.