My only problem with 2400, is that while it's usually accurate the brite white muzzle flash is distracting. 296 and H110 are also bad with the brite white. Medium to warm loads of 4227 tend to be orange in color and not as noticable... at least, it's ok until you get into the max loads when it too gets brite white. I'm not sure there are any powders available that will give top 357 & 44 Mag velocities without the brite white flash. While Accurate said their ball powders were "reduced" flash (as opposed to suppressed flash) hot loads of AA9 will flash just as brite as 2400 & 296, so that's down the tubes! I have loaded reduced loads in 44 Mag using IMR4227 under a 200 gr Speer Gold Dot that results in about 1200 fps and no visible flash at all. But since that bullet was designed for much lower velocity in the .44 Special, the 1200 fps works perfectly as a self/home defense round, although the .44 is not my first choice for that role.
I think a perfect, but no longer available, bullet for deep penetration and no expansion would be tge old Hornady 240 gr Silhouette bullet. Fortunately, I have a few of them all loaded up over a stout load of 296. I would carry those in bear country.
Cheers,
crkckr