I use 78 gr. 8133 in my 65 300 Weatherby with the 143ELDX. That seems to be the sweet spot for my gun, with that bullet. I get 3140 ft./s half inch groups at 100.
I have had good luck with imr8133 so in my 338 lapua. Load data is, lapua brass, cci250 primer, 300 SMK, seated at 3.710. Velocity is right at 2700 FPS. 3 shot group at 100 yards.