Cartridge choices are almost unlimited, which makes picking ONE somewhat difficult. I live in NC, have a lot of weapons to choose from, and the rifle I reach for most often when a .22 won't do is a 25-06. The 25-06 will handle all the range you are apt to have in NC, and do so without leaving cannonball sized holes in game or your wallet. Factory ammunition is readily available, and with this cartridge there is generally no need to reload UNLESS YOU WANT TO.If you were building a new rifle in 25 caliber for hunting and occasional target shooting, which one would it be and why? I'm in western NC so extreme ranges aren't likely but I would like to have the option to shoot the longer heavier bullets but probably would not purpose build it for one particular bullet. I like speed so I am thinking 100-115 grain bullets for the most part but I am open to any and all suggestions. Thanks!