As I have written and commented before on this subject.. there are many really good cartridges out there for coyotes. they are in two classes "hide friendly" and "hide unfriendly".
the hide friendly class would be 17 centerfire (17 Rem, 17-223, 17-222, 17-Mach 4), 22 Hornet, 223/5.56X45, 22-250/22-08, 220 Swift, 223 WSSM, 243 WSSM, 243 win, 6MM rem, and 225 Win.
Hide unfriendly (some of you will not agree with me on this but I have tried many of what I am about to list out.. ) 257 Roberts, 25 WSSM, 25-35, 257 Weatherby, 6.5MM anything, 7MM anything, .270" Anything, .308" Anything or anything larger.
if you are out to make a red mist out of the coyote or are taking 400+ yard shots the hide unfriendly class is the only way to go. My personal faves are 257 Weatherby (two words OVER-KILL) with 100 grain anything that shoots accuratly, 257 Roberts with 90 to 100 grain Nosler B-tips, 270 Winchester with 100 grain Speer HP's
Anything under 350 yard shots I would go with any of the hide friendly rounds. my select few are 223 WSSM, 17 Remington, 257 Roberts. if I am shooting in thick brush and will never take over a 75 yard shot.. the 22 hornet is my best friend with 45 grain V-max.
good hunting gun)
I'm out!