Actually, the 30-06 is as accurate as any other caliber if you load it with the slower powders. I get 5 shot 1 inch groups at 100 yards regularly at distances of 100 yards, and less that 3 inch groups at 300 yards with my Ruger M77MKII and tighter groups with my -03A3. I use 180 grain Speer bullets and 180 grain Sierras. In answer to the original question, the -06 or one of the short 30 magnums would be the best combination of portability, range, recoil tolerance, impact and penetration for anything out to 500 yards, used with either 180 grain or 200 grain bullets. The platform for this round if I were buying it (again) would be the Ruger FTW Hunter or the Remington CDL with a 24 inch barrel, which would give optimum velocity with portability, or a Ruger No1, if you like single shots, in the medium sporter 24 inch barrel, if you can find it. A Ruger Guide Gun would also be ok, but short barrelled. I'd get that in 300 WinMag to make up for barrel length. My actual preference is the .35 Whelen with either 225 grain or 250 grain bullets, loaded to give 2725fps or 2675fps, respectively, out of a Remington CDL. But it kicks a bit, and the -06 is much more forgiving in that area, even with 200 grain bullets clocked at 2600+.