Depends what your objectives are. Bolt gun, speed? 22-250 or AI, 22 Creed. Good speed with more optimal barrel life? 223AI.
AR? Consider 22 ARC though it's not fully released yet.
Either way, the 62gr ELD-VT bullets are worth serious consideration and I'm interested when they get released for real life testing. I've committed to a 22 ARC AR build. I tested the VT blems at Midway in a 223AI at full speed in a 9 twist, I got shotgun patterns though the holes looked round. They call for a 7.5 twist and probably for a reason. Wish I hadn't build my 223AI a year ago with a 9 twist barrel, I would have loved to try them. Will try again when they aren't blems but not hopeful.