Would a better answer be to step down in bullet weight? Either a 165 grain Accubond or a 168 grain Barnes TTSX? How does everyone feel about one of those lighter bullets versus 180 with a little less speed? Am I going down a unnecessary rabbit hole here?
Yes, you are going down a rabbit hole.
From your post 29 "I was thinking if I can get the bullet over 3000 fps, at the muzzle, that will
carry plenty of energy out to 400-500 yds for an ethical kill. I
may be off base, but that was my thinking."
IMO, you are very off base. Energy is probably (IMHO and many others) the most overrated specification there is. All animals die from lack of oxygenated blood to brain whether that is caused by disruption of the CNS, destruction of lung tissues, or destruction the heart etc. The most consistent way to accomplish that is thru shot placement, penetration, and controlled bullet expansion.
The difference in energy (using the 180 Accubond) related to 100 fps at 600 yards is 138 ft lbs. There is not an elk, moose, deer, caribou etc on the planet that can tell the difference.
168s or 180s and a 150 or fps with either is not going to make any difference. One of the things I have learned
from the internet over the last 20+ years is that "Big game animals can tell the difference between .015 of an inch in diameter, 15 grains of bullet weight, and 150 fps."
If you like reloading and playing around with loads. See which one the rifle shoots best and which one you shoot best (recoil does effect the shooters accuracy)
I see you are from Minnesota and don't know the type of hunting you do or where you do it. You would be much better off practicing shooting from the sitting position using a bipod or (my preference) shooting sticks along with your pack tucked under your should or across your thigh. Many times prone is not an option in the West.